The humans are mostly microbes, over 100 trillion of them. Microbes outnumber human cells ten to one. The majority live in the gut, particularly in the large intestine.
The intestinal microbiota is essential for human development, immunity and nutrition. It is a major modifier of health status and disease risk. Loss of microbiota diversity or microbiota alterations are caused by factors including antibiotic usage, habitual dietary patterns, and are linked with significant diseases including obesity, type 2 diabetes, Inflammatory Bowel Disease and Irritable Bowel Syndrome.
Using a combination of in vitro and pre-clinical models, and human dietary challenge we test the ability of defined food ingredients to modulate microbiota diversity, to promote appropriate innate immune function, and to modulate inflammation-related disorders like type 2 diabetes.