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- To screen food ingredients, associated with high diversity microbiota in ELDERMET, in an artificial colon for ability to increase microbiota diversity.
- To establish base-line models of microbiota-inflammatory status in rodents conventionalized with low or high diversity microbiota.
- To translate in vitro findings of microbiota diversity-promoting food ingredients to pre-clinical models, and test dietary supplements for effect on microbiota diversity.
- To determine the effect of microbiota diversity on susceptibility to infection using in vitro and pre-clinical models
- To establish if differential effects upon the microbiota explain differential effects of lipids to cause obesity with or without inflammation in pre-clinical models.
- To establish if the inflammatory activity of lipid fractions can be mitigated by dietary interventions shown above to modulate microbiota diversity.
- To determine by intervention trial if specific dietary ingredients (established from tasks 1-5) can improve gut microbiota diversity in human subjects with a range of metabolic/inflammatory profiles.